C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 41/00 (2006.01) C12P 7/02 (2006.01) C12P 7/18 (2006.01)
Patent
CA 2472178
Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The method can be used, for example, for separating mixed epimers of the vitamin D analog.
L'invention concerne un procédé d'estérification et de solvolyse enzymatiques sélectives d'épimères d'analogues de la vitamine D présentant un centre stéréogénique à la position C-24 qui comprend un groupe OH libre ou estérifié. Le procédé décrit dans cette invention peut être utilisé, par exemple, pour séparer des épimères mélangés de l'analogue de la vitamine D.
Effenberger Reinhard
Fishman Ayelet
Maymon Asher
Schwartz Anchel
Shapiro Evgeny
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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