Selective enzymatic esterification and solvolysis of...

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C12P 7/02 (2006.01) C12P 7/18 (2006.01)

Patent

CA 2472178

Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The method can be used, for example, for separating mixed epimers of the vitamin D analog.

L'invention concerne un procédé d'estérification et de solvolyse enzymatiques sélectives d'épimères d'analogues de la vitamine D présentant un centre stéréogénique à la position C-24 qui comprend un groupe OH libre ou estérifié. Le procédé décrit dans cette invention peut être utilisé, par exemple, pour séparer des épimères mélangés de l'analogue de la vitamine D.

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