C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) A01H 5/00 (2006.01) A01H 5/10 (2006.01)
Patent
CA 2302471
This invention relates to a method of biocatalytically producing compounds that are commercially valuable but are detrimental to the host cells' development. The transgenic plants produced in accordance with the present invention comprise a novel controlled expression system comprising a promoter (2), a blocking sequence (a), and a structural gene (6), wherein the blocking sequence (a) is flanked by a pair of directly repeated site-specific recombination sequences (4). The blocking sequence (a) prevents expression of the structural gene (6) until removal of the blocking sequence (a) by site- specific recombinase activity encoded by a site-specific recombinase gene (12).
L'invention concerne une méthode permettant de produire par biocatalyse des composés commercialement intéressants mais préjudiciables au développement des cellules hôtes. Les végétaux transgéniques produits conformément à la présente invention comprennent un nouveau système d'expression contrôlée comportant un promoteur (2), une séquence bloquante (a), et un gène de structure (6), la séquence bloquante (a) étant encadrée de deux séquences de recombinaison (4) spécifiques à un site directement recopiées. La séquence bloquante (a) empêche l'expression du gène de structure (6) jusqu'à l'élimination de la séquence bloquante (a) sous l'effet de l'activité d'une recombinase spécifique à un site, codée par un gène (12) de recombinase spécifique à un site.
Hodges Thomas K.
Lyznik Leszek A.
Snyder John R.
Purdue Research Foundation
Smart & Biggar
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