Selective glycosidase inhibitors and uses thereof

Details Selective glycosidase inhibitors and uses thereof Selective glycosidase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2732335

The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

L'invention porte sur des composés représentés par la formule (I) pour l'inhibition sélective de glycosidases, sur des promédicaments des composés et sur des compositions pharmaceutiques renfermant les composés ou les promédicaments des composés. L'invention porte également sur des procédés de traitement de maladies et troubles liés à une déficience ou une surexpression de O-GlcNAcase ou à l'accumulation ou la déficience de O-GlcNAc.

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