Selective glycosidase inhibitors and uses thereof

Details Selective glycosidase inhibitors and uses thereof Selective glycosidase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 263/52 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) C07D 277/60 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2732336

The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.

Cette invention concerne des composés de formule (I) inhibant sélectivement les glycosidases, des promédicaments des composés et des compositions pharmaceutiques comprenant les composés et les promédicaments des composés. Linvention concerne également des méthodes de traitement des maladies et des affections associées avec une insuffisance ou une surexpression dO-GlcNAcase, une accumulation ou une insuffisance dO-GlcN Ac.

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