Selective glycosidase inhibitors and uses thereof

Details Selective glycosidase inhibitors and uses thereof Selective glycosidase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/429 (2006.01) C07D 513/14 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2661582

The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc

L'invention concerne des composés pour inhiber de façon sélective les glycosidases, les promédicaments des composés, et des compositions pharmaceutiques comprenant les composés ou les promédicaments des composés. L'invention concerne également des procédés de traitement de maladies et de troubles se rapportant à la déficience ou à la surexpression de O-GlcNAcase, l'accumulation ou la déficience en O-GlcNAc.

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