Selective glycosidase inhibitors and uses thereof

Details Selective glycosidase inhibitors and uses thereof Selective glycosidase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) A61K 31/40 (2006.01) C12Q 1/40 (2006.01)

Patent

CA 2737267

The application relates to an immoalditol compound for selectively inhibiting glycosidases, a prodrug thereof and a pharmaceutical composition comprising the compound or the prodrug The application also relates to the use of the immoalditol compound for treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc Such diseases and disorders include neurodegenerative diseases, tauopathy, cancers, and cardiac disorders

La présente invention concerne un composé immoalditol destiné à inhiber sélectivement des glycosidases, un promédicament de celui-ci et une composition pharmaceutique comprenant le composé ou le promédicament. L'invention concerne également l'utilisation du composé immoalditol pour traiter des maladies et des troubles liés au manque ou à la surexpression de la O-GlcNAcase, l'accumulation ou la manque de O-GlcNAc. Les maladies et troubles de ce type comprennent les maladies neurodégénératives, les tauopathies, les cancers et les troubles cardiaques.

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