C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/00 (2006.01) A61K 31/35 (2006.01) A61K 31/427 (2006.01) A61K 31/445 (2006.01) C07D 211/56 (2006.01) C07D 277/62 (2006.01) C07D 309/14 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2599843
The invention comprises compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions containing the compounds or prodrugs of the compounds. The invention also comprises animal models and methods of making the animal models for studying diseases and disorders related to deficiency or overexpression of O-GIcNAcase, accumulation or deficiency of O-GIcNAc, and treatment of such diseases and disorders. The invention also comprises methods of treating such diseases and disorders. The invention also comprises methods of making the compounds, and methods of making selective glycosidase inhibitors.
L~invention comprend des composés inhibiteurs sélectifs de glycosidases, des médicaments dérivés des composés, et des compositions pharmaceutiques contenant les composés ou les médicaments dérivés des composés. L~invention comprend également des modèles animaux et des procédés de fabrication des modèles animaux pour étudier les maladies et les troubles liés à la déficience ou une surexpression d~O-GIcNAcase, l~accumulation ou la déficience d~O-GIcNAc, et le traitement de telles maladies et de tels troubles. L~invention concerne par ailleurs des procédés de traitement de telles maladies et de tels troubles. L~invention porte en outre sur des procédés de fabrication des composés et des procédés de fabrication d~inhibiteurs sélectifs de glycosidase.
Macauley Matthew
Stubbs Keith
Vocadlo David
Whitworth Garrett
Borden Ladner Gervais Llp
Simon Fraser University
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