A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 51/06 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2721980
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
La présente invention concerne des ligands polydentés sélectifs à haute affinité (SHAL) inédits, pouvant être utilisés dans diverses applications de façon analogue à des anticorps. Les SHAL comprennent généralement une multiplicité de ligands qui lient chacun une région différente de la molécule cible. Les ligands sont reliés directement, ou par l'intermédiaire d'une séquence de liaison, et forment un groupe polydenté liant, en règle générale, la molécule cible avec une grande sélectivité et une grande avidité.
Balhorn Rodney L.
Denardo Gerald L.
Denardo Sally J.
Borden Ladner Gervais Llp
Lawrence Livermore National Security Llc
The Regents Of The University Of California
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