Selective induction of cell death by delivery of...

Details Selective induction of cell death by delivery of... Selective induction of cell death by delivery of...

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/545 (2006.01) C09H 3/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2288967

The present invention is directed to compositions and methods for selective induction of apoptosis in cancer cells, particularly malignant cancer cells, by delivery of an IL-1.alpha. propiece polypeptide (e.g., a native IL-1.alpha. propiece polypeptide, including IL-1.alpha. propiece polypeptide variant) to a cancer cell.

L'invention concerne des compositions et des procédés servant à effectuer l'induction sélective de l'apoptose dans des cellules cancéreuses, en particulier, des cellules malignes, par administration d'un polypeptide de moitié de terminaison N IL-1.alpha. (par exemple, un polypeptide natif de moitié de terminaison N IL-1.alpha., y compris une variante de ce dernier) à une cellule cancéreuse.

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