Selective inhibition of nf-kappab activation by peptides...

Details Selective inhibition of nf-kappab activation by peptides... Selective inhibition of nf-kappab activation by peptides...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2540103

The present invention relates to polypeptides that inhibit the NF-&kgr;B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.

La présente invention se rapporte à des polypeptides inhibant la voie de signalisation de NF-?B, et à des polynucléotides codant pour ces polypeptides. La présente invention se rapporte également à des procédés de modulation et/ou de traitement des réponses inflammatoires, de l'oncogenèse, et des infections virales ; à la régulation de la prolifération cellulaire et de l'apoptose ; et à la régulation des lymphocytes B ou T dans la stimulation antigénique, par administration des polypeptides selon la présente invention à un sujet qui en a besoin. Enfin, la présente invention se rapporte à un procédé d'identification de polypeptides qui modulent l'oligomérisation de la protéine NEMO.

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