Selective inhibition of polyglutamine protein expression

Details Selective inhibition of polyglutamine protein expression Selective inhibition of polyglutamine protein expression

A - Human Necessities

61

K

A61K 31/80 (2006.01) A61K 31/785 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2732343

The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntingtin using nucleic acid analogs. Peptide nucleic acids and locked nucleic acids are particularly useful analogs.

La présente invention concerne l'inhibition sélective d'expression protéinique de protéine de maladie en rapport avec une répétition de CAG, comme la maladie d'Huntington, en utilisant des analogues d'acide nucléique. Des acides nucléiques peptidiques et les acides nucléiques verrouillés sont des analogues particulièrement utiles.

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