Selective inhibitors against cdk4 and cdk6 having...

Details Selective inhibitors against cdk4 and cdk6 having... Selective inhibitors against cdk4 and cdk6 having...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/506 (2006.01) A61K 31/513 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 417/14 (2006.01) C07D 491/08 (2006.01)

Patent

CA 2567569

Compounds represented by the general formula [I] or pharmaceutically acceptable salts or esters thereof; and selective inhibitors against Cdk4 and/or Cdk6 or anticancer agents, containing the same: [I] wherein X is O, S, NH, or CH2; Y1, Y2, Y3, Y4 and Y5 are each independently CH or N with at least one of Y1, Y2, Y3, Y4 and Y5 being N; Z1 and Z2 are each independently CH or N; n is an integer of 1 to 3; R1 is C3-8 cycloalkyl, C6-10 aryl, an aliphatic or aromatic heterocycle, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3 are each independently hydrogen, lower alkyl, lower alkenyl, C3-8 cycloalkyl, C6-10 aryl, an aromatic heterocycle, or the like; and R4 is hydrogen, lower alkyl, C3-6 cycloalkyl, or the like.

Des composés représentés par la formule générale [I] ou des esters ou sels pharmaceutiquement acceptables ; et des inhibiteurs sélectifs contre les Cdk4 et/ou Cdk6 ou les agents anticancéreux, contenant le même : [I] où X est O, S, NH, ou CH2 ; Y1, Y2, Y3, Y4 et Y5 sont chacun indépendamment CH ou N avec au moins un de Y1, Y2, Y3, Y4 et Y5 étant N ; Z1 et Z2 sont chacun indépendamment CH ou N ; n est un entier de 1 à 3 ; R1 est C3-8 cycloalkyle, C6-10 aryle, un hétérocycle aliphatique ou aromatique ou un groupe d'hydrocarbure saturé aliphatique bicyclique ; R2 et R3 sont chacun indépendamment de l'hydrogène, de l'alkyle plus faible, de l'alkényle plus faible, du C3-8 cycloalkyle, du C6-10 aryle, un hétérocycle aromatique, ou semblable ; et R4 est de l'hydrogène, de l'alkyle plus faible, du C3-6 cycloalkyle, ou semblable.

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