Selective inhibitors for cyclin-dependent kinases

Details Selective inhibitors for cyclin-dependent kinases Selective inhibitors for cyclin-dependent kinases

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2688616

This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infections (e.g., HIV) neurodegenerative disorders (e.g. Alzheimer's disease), and cardiovascular disorders (e.g. atherosclerosis). Moreover, certain members of this class are particularly useful for inhibiting cyclin-dependent kinase 7 and are especially useful for the treatment of breast cancer.

La présente invention concerne une catégorie de composés utilisables en vue de l'inhibition sélective des kinases cycline-dépendantes. Cette catégorie de composés est utilisable dans le cadre du traitement de maladies résultant d'une activité peu appropriée des kinases cycline-dépendantes, dont les cancers, les infections virales (par exemple par le VIH), les troubles neurodégénératifs (par exemple la maladie d'Alzheimer) et les affections cardiovasculaires (par exemple l'athérosclérose). En outre, certains membres de cette catégorie peuvent plus particulièrement être utilisés en vue de l'inhibition de la kinase cycline-dépendante 7 et se révèlent tout particulièrement utiles en vue du traitement du cancer du sein.

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