Selective inhibitors of akt and methods of using same

Details Selective inhibitors of akt and methods of using same Selective inhibitors of akt and methods of using same

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4704 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01) C07D 215/227 (2006.01)

Patent

CA 2747817

The present invention describes an improved method for screening compounds for activity in inhibiting the enzymatic activity of Akt1 protein kinase, also known as Protein Kinase B, an enzyme that is believed to playa key role in the inhibition of apoptosis and thus in the etiology of cancer and other conditions, including neurodegenerative diseases.

La présente invention concerne un procédé amélioré de criblage de composés pour une activité d'inhibition de l'activité enzymatique de la protéine kinase Akt1, également connue sous le nom de protéine kinase B, une enzyme que l'on suppose jouer un rôle clé dans l'inhibition de l'apoptose et ainsi dans l'étiologie du cancer et d'autres pathologies, parmi lesquelles les maladies neurodégénératives.

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