C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/20 (2006.01) A61K 31/222 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2276398
The present invention provides a compound of formula (I), wherein R is selected from the group consisting of CH3, CH2CH3, (CH2)2CH3, (CH2)3CH3, (CH2)4CH3, (CH2)5CH3, (CH2)6CH3, (CH2)2O(CH2)3CH3, CH2HC=CH(CH2)3CH3, CH2CC(CH2)3CH3, CCH2CC(CH2)2CH3, CH2CC-CCH2CH3, CH2CC-CH3 and CH2CCH; and R' is selected from the group consisting of CH3, CF3, CH2Cl and CH2Br or a pharmaceutically acceptable salt or hydrate thereof. Also provided is a method of inhibiting the synthesis of prostaglandin endoperoxide syntase-2 (PGHS-2) in a mammal.
La présente invention concerne un composé de formule (I) dans laquelle R est sélectionné dans le groupe comprenant CH¿3?, CH¿2?CH¿3?, (CH¿2?)¿2?CH¿3?, (CH¿2?)¿3?CH¿3?, (CH¿2?)¿4?CH¿3?, (CH¿2?)¿5?CH¿3?, (CH¿2?)¿6?CH¿3?, (CH¿2?)¿2?O(CH¿2?)¿3?CH¿3?, CH¿2?HC=CH(CH¿2?)¿3?CH¿3?, CH¿2?C?C(CH¿2?)¿3?CH¿3?, CCH¿2?C?C(CH¿2?)¿2?CH¿3?, CHC¿2?C?C-CCH¿2?CH¿3?, CH¿2?C?C-CH¿3?, et CH¿2?C?CH; et R' est sélectionné dans le groupe comprenant CH¿3?, CF¿3?, CH¿2?Cl et CH¿2?Br ou un sel ou un hydrate pharmaceutiquement acceptable dudit composé. L'invention concerne également un procédé pour inhiber la synthèse de la prostaglandine endoperoxyde synthase-2 (PGHS-2) chez un mammifère.
Kalgutkar Amit S.
Marnett Lawrence J.
Borden Ladner Gervais Llp
Vanderbilt University
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