C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2473229
The present invention features truncated hMCH analogs selectively active at MCH-1R over MCH-2R. Using amino acid numbering provided in hMCH, the featured analogs contain an X6 which is either a D-amino acid, 5-guanidinopropionic acid or its lower or higher homolog, or a derivative thereof; and a X10 which is either asparagine, glutamine, alanine, leucine, isoleucine, valine, norleucine, cyclohexylalanine, phenylalanine, (2')-naphthylalanine, tyrosine, histidine, tryptophan, lysine, serine, threonine, methionine, or a derivative thereof.
L'invention concerne des analogues de la hMCH tronquée, actifs de manière sélective sur la MCH-1R et sur la MCH-2R. Au moyen d'une numérotation d'aminoacide effectuée dans la hMCH, les analogues de l'invention contiennent un X?6¿ qui représente soit un aminoacide-D, un acide 5-guanidinepropionique ou son homologue supérieur ou inférieur, ou un de ses dérivés ; et un X?10¿ qui représente soit asparagine, glutamine, alanine, leucine, isoleucine, valine, norleucine, cyclohexylalanine, phénylalanine, (2')-naphtylalanine, tyrosine, histidine, tryptophane, lysine, sérine, thréonine, méthionine, ou un de leurs dérivés.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
LandOfFree
Selective melanin-concentrating hormone type -1 receptor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Selective melanin-concentrating hormone type -1 receptor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Selective melanin-concentrating hormone type -1 receptor... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1709590