Selective mmp inhibitors having reduced side-effects

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/55 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2280134

A matrix metalloproteinase (MMP) inhibitor that exhibits an IC50 of below 10- 4M against MMP and has substantially no activity against non-MMP metalloproteinase-related events has reduced side-effects, especially with respect to joint pain.

L'invention concerne un inhibiteur de la métalloprotéase matricielle qui présente une concentration inhibitrice ¿50? de moins de 10?-4¿M contre la métalloprotéase matricielle, et n'exerce sensiblement aucune activité contre les évènements non liés à la métalloprotéase matricielle. Cet inhibiteur présente des effets secondaires réduits, en particulier, dans le domaine des douleurs articulaires.

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