Selective non-steroidal glucocorticoid receptor modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/54 (2006.01) A61K 31/416 (2006.01) A61K 31/4178 (2006.01) A61K 31/506 (2006.01) C07D 403/08 (2006.01) C07D 409/08 (2006.01)

Patent

CA 2516684

The present invention encompasses compounds of Formula (I) or pharmaceutically acceptable salts or hydrates thereof, which are useful as novel non-steroidal selective glucocorticoid receptor modulators for treating a variety of autoimmune and inflammatory diseases or conditions, and possess advantages over steroidal glucocorticoid ligands with respect to undesireable side- effects, efficacy, toxicity and/or metabolism. Pharmaceutical compositions and methods of use are also included.

L'invention concerne des composés représentés par la formule (I) ou des sels pharmaceutiquement acceptables ou des hydrates de ceux-ci, utilisés comme nouveaux modulateurs sélectifs de récepteurs de glucocorticoïdes non-stéroïdaux afin de traiter une variété de maladies ou d'états auto-immunes et inflammatoires. Ces composés présentent des avantages par rapport aux ligands de glucocorticoïdes stéroïdaux en ce qui concerne les effets secondaires indésirables, l'efficacité, la toxicité et/ou le métabolisme. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation.

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