Selective npy (y5) antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/44 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) C07D 233/54 (2006.01) C07D 263/30 (2006.01) C07D 277/42 (2006.01) C07D 277/60 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2380866

This invention is directed to bicyclic and tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of this invention and a pharmaceutically acceptable carrier. The invention provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides the use of a compound of the invention for the preparation of a pharmaceutical composition for treating an abnormality, wherein the abnormality is alleviated by decreasing the activity of a human Y5 receptor.

L'invention se rapporte à des composés bicycliques et tricycliques qui sont des antagonistes sélectifs des récepteurs du NPY (Y5). L'invention se rapporte à une composition pharmaceutique comportant une quantité thérapeutiquement active d'un tel composé et un excipient pharmaceutiquement acceptable. Cette invention se rapporte à une composition pharmaceutiquement acceptable que l'on fabrique en combinant une quantité thérapeutiquement efficace d'un tel composé et d'un excipient pharmaceutiquement acceptable. Elle se rapporte également à un procédé de fabrication d'une composition pharmaceutique consistant à combiner une quantité thérapeutiquement efficace d'un tel composé et d'un excipient pharmaceutiquement acceptable. Cette invention se rapporte également à l'utilisation d'un composé décrit ci-dessus pour la préparation d'une composition pharmaceutique destinée au traitement d'une anomalie qu'il est possible d'atténuer en réduisant l'activité d'un récepteur humain de Y5.

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