Selective o-acylation of nucleosides

Details Selective o-acylation of nucleosides Selective o-acylation of nucleosides

C - Chemistry, Metallurgy

07

H

C07H 19/09 (2006.01) C07H 19/067 (2006.01) C07H 19/073 (2006.01) C07H 19/167 (2006.01) C07H 19/173 (2006.01)

Patent

CA 2622191

The present invention relates to a one-step process for the selective O- acylation of the hydroxy groups of a nucleoside under basic conditions utilizing DMAP and a carboxylic acid anhydride in aqueous heterogenous solvent mixture.

La présente invention concerne un procédé d'une seule étape destiné à l'O-acylation des groupes hydroxy d'un nucléoside dans des conditions basiques utilisant le DMAP et un anhydride d'acide carboxylique dans un mélange solvant aqueux.

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