Selective opioid compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 221/28 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01) C07D 489/00 (2006.01)

Patent

CA 2714331

The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (I) or (II) which relates to mophinan compounds useful as µ, .delta. and/or .kappa. receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.

La présente invention porte sur les composés représentés par la formule I ou II, ou sur des sels pharmaceutiquement acceptables, esters ou promédicaments de ceux-ci : (I) ou (II) désignant les composés morphiniques utiles tels que les composés opioïdes des récepteurs, d et/ou ? et les substances pharmaceutiques contenant lesdits composés et pouvant se révéler utiles pour faciliter lanalgésie, pour combattre laddiction aux drogues, laddiction à l'alcool, la surdose de drogue, la maladie mentale, les dysfonctionnements de la vessie, la vessie neurogène, la cystite interstitielle, lincontinence urinaire, léjaculation précoce, la douleur inflammatoire, la douleur neuropathique et notamment périphérique, la toux, ldème pulmonaire, la diarrhée, les troubles cardiaques, pour la cardioprotection, dans le cas de dépression, de troubles cognitifs, respiratoires, de diarrhée, de syndrome du côlon irritable et de troubles gastro-intestinaux, pour limmunomodulation et en tant quagents anti-tumoraux.

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