Selective pharmacologic inhibition of protein trafficking...

Details Selective pharmacologic inhibition of protein trafficking... Selective pharmacologic inhibition of protein trafficking...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/404 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/4188 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2533990

Preferred aspects of the present invention relate to the inhibition of intracellular protein trafficking pathways through selective pharmacologic down-regulation of specific resident ER and golgi proteins, and more particularly, to methods of treating a variety of disease conditions, which depend on these intracellular protein trafficking pathways.

Dans des modes de réalisation préférés, la présente invention concerne l'inhibition de mécanismes du trafic de protéines intracellulaires par régulation négative pharmacologique sélective de protéines du réticulum endoplasmique (ER) et du complexe de Golgi résidentes, spécifiques, et plus particulièrement, des méthodes de traitement d'une variété d'états pathologiques, lesquels dépendent desdits mécanismes du trafic de protéines intracellulaires.

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