Selective process for the deacylation of acylated compounds

Details Selective process for the deacylation of acylated compounds Selective process for the deacylation of acylated compounds

C - Chemistry, Metallurgy

12

P

C12P 7/62 (2006.01) C07C 69/732 (2006.01)

Patent

CA 2201729

The invention provides a simple and selective method for the deacylation of 4- acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.

L'invention concerne un procédé simple et sélectif de désacylation de statines acylés en position 4 au cours de la préparation de statines à partir d'un bouillon de fermentation, et plus précisément de réduction des impuretés liées au processus, par augmentation du pH de ce bouillon de fermentation.

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