Selectively binding ultrasound contrast agents

Details Selectively binding ultrasound contrast agents Selectively binding ultrasound contrast agents

A - Human Necessities

61

K

A61K 49/04 (2006.01) A61K 9/127 (2006.01) A61K 9/16 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2288013

The invention discloses an ultrasound contrast media comprising a microbubble shell and a composition of general formula: A-P-L, wherein A is an ultrasound contrast agent microbubble-shell binding moiety; P is a spacer arm; and L is a ligand. The present invention discloses compositions, methods of imaging, and methods for attachment of targeting ligands to USCM agents, allowing selective targeting of USCM agents to desired sites.

L'invention concerne un support de contraste pour ultrasons (USCM), qui comporte une enveloppe de microbulles et une composition représentée par la formule générale: A-P-L, dans laquelle A est une fraction fixatrice d'enveloppe de microbulles d'agent de contraste pour ultrasons; P est un bras espaceur; et L est un ligand. La présente invention concerne des compositions, des procédés d'imagerie et des procédés visant à la fixation de ligands de ciblage à des agents d'USCM, qui permettent un ciblage sélectif d'agents d'USCM vers des sites voulus.

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