Selectively deglycosylated human immunodeficiency virus type...

Details Selectively deglycosylated human immunodeficiency virus type... Selectively deglycosylated human immunodeficiency virus type...

C - Chemistry, Metallurgy

07

K

C07K 16/10 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 14/16 (2006.01) C12P 21/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2131909

2131909 9317705 PCTABS00025 Disclosed are methods for selectively deglycosylating HIV-1 envelope protein which retain their ability to support viral infectivity. The deglycosylation is achieved by generating recombinant HIV-1 envelope glycoproteins which have primary amino acid sequence mutations in the N-linked glycosylation consensus sequences. Also disclosed are vaccines and antibodies to the mutant recombinant HIV-1 envelope glycoproteins.

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