Selenium containing modifying agents and conjugates

Details Selenium containing modifying agents and conjugates Selenium containing modifying agents and conjugates

C - Chemistry, Metallurgy

08

G

C08G 65/337 (2006.01) A61K 47/48 (2006.01) C07K 14/535 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2717276

The invention relates to a modifying agent comprising a water soluble polymer, wherein the water soluble polymer comprises at least one reactive selenium group, said reactive selenium group being capable of reacting with a thiol group thereby forming an -Se-S- bond. Furthermore, the invention relates to a method for producing said modifying agents and their use in the modification of pharmaceutically active agents, e.g. G-CSF. Additionally, the invention concerns conjugates comprising a water-soluble polymer and a pharmaceutically active agent, wherein the water-soluble polymer is linked via a S-Se-bond to agent and a method for their production and their use as medicaments. Finally, the invention concerns a pharmaceutical composition comprising the inventive conjugates.

La présente invention concerne un agent de modification comprenant un polymère hydrosoluble, ledit polymère hydrosoluble comprenant au moins un groupe sélénium réactif, et ledit groupe sélénium réactif étant capable de réagir avec un groupe thiol, ce qui forme une liaison -Se-S-. L'invention concerne également un procédé de production des agents de modification et leur utilisation pour modifier des agents pharmaceutiquement actifs, par exemple, le G-CSF. L'invention concerne. en outre, des conjugués comprenant un polymère hydrosoluble et un agent pharmaceutiquement actif, le polymère hydrosoluble étant lié à un agent par l'intermédiaire d'une liaison -S-Se-, et un procédé pour leur production et leur utilisation en tant que médicaments. Finalement, l'invention concerne une composition pharmaceutique renfermant les conjugués de l'invention.

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