Self-assembling amphiphilic polymers as anticancer agents

A - Human Necessities – 61 – K

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Details

A61K 47/34 (2006.01) A61K 9/107 (2006.01) C08G 63/672 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2691002

The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.

L'invention porte sur des copolymères biocompatibles amphiphiles qui ont un squelette hydrophile et des groupes hydrophobes pendants. Les polymères forment des agrégats moléculaires à l'échelle nanométrique dans des environnements aqueux, qui ont des intérieurs hydrophobes à l'intérieur desquels des médicaments anticancer peuvent être solubilisés. Les polymères présentent facultativement des anticorps fixés, des ligands de récepteurs et autres fractions de ciblage qui font la médiation entre l'adhérence des agrégats portant le médicament et des cellules cancéreuses ciblées.

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