Self-assembling amphiphilic polymers as antiviral agents

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 7/08 (2006.01) A61K 31/795 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 47/48 (2006.01) A61P 31/14 (2006.01) A61P 31/16 (2006.01) C07K 7/06 (2006.01) C07K 16/10 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2676239

There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds and disrupting viral coat proteins. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties which mediate adherence of the aggregate to a viral target.

L'invention concerne des copolymères biodégradables amphiphiles comprenant un squelette hydrophile avec des groupes aliphatiques pendants comme composant hydrophobe. Les polymères forment des agrégats moléculaires à l'échelle nanométrique dans des environnements aqueux, ayant des intérieurs hydrophobes lesquels sont capables de solubiliser des composés organiques insolubles et de rompre des protéines d'enveloppe virale. Les polymères présentent facultativement des groupes fonctionnels réactifs fournissant des points de fixation pour des anticorps, des ligands et autres fractions de ciblage assurant la médiation d'une adhérence de l'agrégat à une cible virale.

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