C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/395 (2006.01) C07K 14/245 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/26 (2006.01) C07K 16/46 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2468583
There is provided a method of forming a multimeric complex having affinity for a target. The method comprises: obtaining a plurality of self-assembly molecules, said self-assembly molecules including complementary self-assembly units such as verotoxin subunit B, each of which is operatively connected to an interaction domain such as a single domain antibody specific for the target; and combining said self-assembly molecules such that at least three said self-assembly units simultaneously bind to one another so as to permit the single domain antibodies to bind the target.
La présente invention concerne un procédé permettant la formation d'un complexe multimère ayant de l'affinité pour une cible. Le procédé comprend les étapes suivantes: obtention d'une pluralité de molécules d'auto-assemblage qui comprennent des unités d'auto-assemblage complémentaires telles que la sous-unité vérotoxine B, chacune des unités étant liée d'un point de vue fonctionnel à un domaine d'interaction tel qu'un anticorps à domaine unique spécifique de la cible; et combinaison desdites molécules d'auto-assemblage de sorte qu'au moins trois desdites unités d'auto-assemblage se lient simultanément entre elles pour permettre aux anticorps à domaine unique de se lier à la cible.
Mackenzie C. Roger
Zhang Jianbing
National Research Council Of Canada
Ridout & Maybee Llp
LandOfFree
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