Self-assembling nanoparticle drug delivery system

Details Self-assembling nanoparticle drug delivery system Self-assembling nanoparticle drug delivery system

C - Chemistry, Metallurgy

07

K

C07K 14/02 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2683063

A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the bioactive agent, a lipid layer or lipid/cholesterol layer coat and targeting or facilitating molecules anchored in the lipid layer. A method for construction of the self-assembling nanoparticle drug delivery system is also provided.

L'invention concerne un système de relargage de médicaments par auto-assemblage de nanoparticules, destiné à l'administration de divers agents bioactifs comprenant des peptides, des protéines, des acides nucléiques ou des médicaments chimiques de synthèse. Le présent système de relargage de médicaments par auto-assemblage de nanoparticules comprend des protéines de capsides virales, telles qu'une protéine du noyau du virus de l'hépatite B, encapsulant l'agent bioactif, une couche de lipides ou une couche lipides-cholestérol et des molécules de ciblage ou auxiliaires ancrées dans la couche de lipides. L'invention concerne également un procédé permettant la construction du système de relargage de médicaments par auto-assemblage de nanoparticules.

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