A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01) A61K 9/127 (2006.01) C07K 14/02 (2006.01)
Patent
CA 2567741
A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the drug, a lipid bi-layer envelope and targeting or facilitating molecules anchored in the lipid bilayer. A method for construction of the self-assembling nanocparticle drug delivery system is also provided.
L'invention concerne un système d'administration de médicaments à base de nanoparticules à autoassemblage, destiné à l'administration de médicaments, y compris de peptides, de protéines, d'acides nucléiques ou de médicaments chimiques de synthèse. Ce système d'administration de médicaments à base de nanoparticules à autoassemblage comprend des protéines de capsides virales, telles qu'une protéine du noyau du virus de l'hépatite B, encapsulant le médicament, une enveloppe bicouche lipidique et des molécules de ciblage ou auxiliaires ancrées dans le bicouche lipidique. L'invention concerne également une méthode permettant de construire ce système de distribution de médicaments à base de nanoparticules à autoassemblage.
de Los Rios Miguel A.
Oh Kenneth J.
Chimeracore Inc.
Chimeros Inc.
Smart & Biggar
LandOfFree
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