Self-assembling nanoparticles composed of transmembrane...

A - Human Necessities – 61 – K

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Details

A61K 9/51 (2006.01) A61K 38/00 (2006.01) A61K 47/42 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2668638

The invention provides a method of handling a hydrophobic agent, which method comprises (a) combining in an aqueous solution (i) a hydrophobic agent and (ii) an isolated peptide that is a structural analog of a transmembrane domain of an integral membrane protein, wherein one terminus of the peptide has one or more negatively charged residues, and (b) allowing the peptide to self-assemble into nanoparticles, wherein the nanoparticles comprise the hydrophobic agent.

L'invention concerne un procédé de manipulation d'un agent hydrophobe, le procédé comprenant (a) la combinaison dans une solution aqueuse (i) d'un agent hydrophobe et (ii) d'un peptide isolé qui est un analogue structurel d'un domaine transmembranaire d'une protéine membranaire en un seul bloc, une terminaison du peptide ayant un ou plusieurs résidus chargés négativement, et (b) la possibilité pour le peptide de s'auto-assembler dans des nanoparticules, les nanoparticules comprenant l'agent hydrophobe.

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