Self-assembling peptide nanoparticles useful as vaccines

Details Self-assembling peptide nanoparticles useful as vaccines Self-assembling peptide nanoparticles useful as vaccines

C - Chemistry, Metallurgy

07

K

C07K 14/445 (2006.01) A61K 39/385 (2006.01) A61P 37/04 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2713879

Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and/or B-cell epitopes are described. The nanoparticles of the invention consist of aggregates of a continuous peptidic chain comprising two oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes and/or B-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants.

L'invention concerne des nanoparticules peptidiques à auto-assemblage (SAPN) incorporant des épitopes de lymphocytes T et/ou des épitopes de lymphocytes B. Les nanoparticules de l'invention sont constituées d'agrégats d'une chaîne peptidique continue comprenant deux domaines d'oligomérisation reliés par un segment lieur, un des domaines ou les deux domaines d'oligomérisation incorporant des épitopes de lymphocytes T et/ou des épitopes de lymphocytes B dans leur séquence peptidique. Ces nanoparticules sont utiles comme vaccins et adjuvants.

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