Self-assembling polynucleotide delivery system

Details Self-assembling polynucleotide delivery system Self-assembling polynucleotide delivery system

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 9/72 (2006.01) A61K 31/70 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07D 401/14 (2006.01) C07D 471/02 (2006.01) C07D 498/14 (2006.01) C07F 9/09 (2006.01) C07F 9/10 (2006.01) C07K 14/025 (2006.01) C08G 83/00 (2006.01) C09B 1/515 (2006.01)

Patent

CA 2133323

This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via noncovalent interactions with the polynucleotide. The components of this system include DNA-masking components, cell recognition components, charge-neutralization and membrane-per-meabilization components, and subcellular localization components. Specific compounds useful in this system are also provided.

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