Self-assembling recombinant papillomavirus capsid proteins

Details Self-assembling recombinant papillomavirus capsid proteins Self-assembling recombinant papillomavirus capsid proteins

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/81 (2006.01) C12N 15/86 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2143845

Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence pro- teins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

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