Self-cleaving ribozymes and uses thereof

Details Self-cleaving ribozymes and uses thereof Self-cleaving ribozymes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) C12N 7/01 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/86 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2545697

In certain embodiment, the disclosure relates to compositions and methods relating to a ribozyme-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to schistosome self-cleaving RNA mutant motifs.

Dans un certain mode de réalisation, cette invention concerne des compositions et des méthodes portant sur un système de régulation génique à partir des rybozymes à l'oeuvre dans des cellules de mammifères. Dans certains modes de réalisation spécifiques,, l'invention concerne des motifs mutants d'ARN de schistozome à autoclivage.

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