Self-cleaving rna sequences and their use for the control of...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/63 (2006.01) C12N 9/00 (2006.01) C12N 15/10 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2387185

This invention relates to the control of protein synthesis from a mRNA sequence (activation or repression) by inserting a sequence into an untranslated region (UTR) of a gene which confers conditional self-cleavage to the transcribed RNA.

La présente invention concerne la régulation de la synthèse protéique à partir d'une séquence d'ARNm (activation ou répression), consistant à insérer une séquence dans une région non traduite (UTR) d'un gène conférant à l'ARN transcrit un auto-clivage conditionnel.

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