Self-emulsifying systems containing anticancer medicament

Details Self-emulsifying systems containing anticancer medicament Self-emulsifying systems containing anticancer medicament

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 9/107 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2377086

The present invention relates to a stabilized self-emulsifying system, comprising a therapeutically effective amount of <i>o</i>- (chloroacetylcarbamoyl)fumigillol, a pharmaceutically acceptable carrier and a stabilizing component, wherein the pharmaceutically acceptable carrier comprises an oily constituent and at least one surfactant. The stabilizing component comprises from about 1% to about 15% water relative to the weight of the self-emulsifying system, an acid, an adsorbent, or a complex-forming agent.

La présente invention concerne un système auto-émulsifiant comprenant une quantité thérapeutiquement efficace de <i>o</i>-(chloroacétylcarbamoyl)fumigillol, un excipient pharmaceutiquement acceptable et un composant de stabilisation, ledit excipient pharmaceutiquement acceptable contenant un constituant huileux et au moins un surfactant. Le composant de stabilisation contient entre 1 % et environ 15 % d'eau par rapport au poids du système auto-émulsifiant, un acide, un absorbant ou un complexant.

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