Self-extinguishing recombinases, nucleic acids encoding them...

Details Self-extinguishing recombinases, nucleic acids encoding them... Self-extinguishing recombinases, nucleic acids encoding them...

C - Chemistry, Metallurgy

12

N

C12N 15/79 (2006.01) A01H 5/00 (2006.01) A01K 67/00 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/10 (2006.01) C12N 15/82 (2006.01) C12N 15/86 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2405768

Nucleic acid molecules comprising at least a first signal site and a recombinase gene operably linked to an expression control sequence, such that upon entry into a cell, there is a first signal site and a second signal site positioned to mediate excision of a sufficient portion of either the recombinase gene or the expression control sequence to extinguish recombinase activity when the first and second signal sites are contacted with a recombinase, cells, transgenics and uses of the foregoing.

La présente invention concerne des molécules d'acide nucléique comprenant au moins un premier signal de site, et un gène recombinase lié de manière fonctionnelle à une séquence de régulation d'expression, de telle sorte que lors de la pénétration dans une cellule, le premier signal de site et le second signal de site se positionnent de manière à servir d'intermédiaires pour l'excision d'une portion suffisante du gène recombinase ou bien de la séquence de régulation d'expression pour mettre fin à l'activité de la recombinase lorsque le premier et le second signal de site entrent en contact avec une recombinase, cette invention concernant en outre des cellules, des transgènes et des utilisations de ces molécules.

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