Self-folding polymer microparticles

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/00 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 47/48 (2006.01) B01J 13/04 (2006.01) B05D 1/38 (2006.01) B05D 3/10 (2006.01) B05D 3/12 (2006.01) B05D 7/04 (2006.01)

Patent

CA 2504842

A method for forming three-dimensional polymeric particulate microstructures through self-folding of thin-film microparticles. Self-folding of two- dimensional polymeric precursors produces various three-dimensional particulate microstructures. Dumpling-like microstructures with oil cores and polymer coats are prepared by an interfacial-tension driven self-folding method. Roll-like and bowl-shaped hydrogel microstructures are fabricated by self-folding induced by differential volume shrinkage. Curled microstructures are produced by self-folding that is the result of a two-polymer or bilayer method wherein one of the polymers is a volume changeable polymer.

L'invention concerne un procédé permettant de former des microstructures particulaires polymères tridimensionnelles par repliement automatique de microparticules de film mince. Le repliement de deux précurseurs polymères bidimentionnels produit des microstructures particulaires tridimensionnelles variées. Des microstructures du type oblong comprenant des noyaux huileux et des revêtements polymères sont préparées à l'aide d'un procédé de repliement automatique entraîné par une tension interfaciale. Des microstructures d'hydrogel du type cylindre et en forme de coupe sont fabriquées par auto-repliement induit par une diminution de volume différentiel. Des microstructures frisées sont produites par auto-repliement qui résulte de l'utilisation d'un procédé mettant en oeuvre deux polymères ou deux couches, l'un des polymères étant un polymère dont le volume peut changer.

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