Self-gelling alginate systems and uses thereof

Details Self-gelling alginate systems and uses thereof Self-gelling alginate systems and uses thereof

A - Human Necessities

61

K

A61K 31/729 (2006.01)

Patent

CA 2583373

Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a self-gelling alginate dispersion are disclosed. The methods comprise forming a dispersion of insoluble alginate/gelling ion particles in a solution containing soluble alginate, and dispensing the dispersion whereby the dispersion forms an alginate gel matrix. The methods may include dispensing the dispersion into the body of an individual. An alginate gel having a thickness of greater than 5 mm and a homogenous alginate matrix network and homogenous alginate gels free of one or more of: sulfates citrates, phosphates, lactatates, EDTA or lipids are disclosed. Implantable devices comprising a homogenous alginate gel coating are disclosed. Methods of improving the viability of pancreatic islets, or other cellular aggregates or tissue, following isolation and during storage and transport are disclosed.

L'invention concerne des kits et des compositions permettant de produire un gel d'alginate. Les kits et compositions de l'invention comprennent des particules ioniques gélifiantes d'alginate solubles et insolubles. L'invention concerne des procédés qui consistent à former une dispersion de particules ioniques gélifiantes d'alginate insolubles dans une solution contenant de l'alginate soluble ; et à distribuer la dispersion, laquelle forme une matrice de gel d'alginate. Les procédés de l'invention peuvent consister à distribuer la dispersion dans le corps d'un individu. L'invention concerne également un gel d'alginate présentant une épaisseur supérieure à 5 mm et un réseau de matrice d'alginate homogène et des gels d'alginate homogènes exempts des éléments suivants : sulfates, citrates, phosphates, lactates, EDTA ou lipides. L'invention concerne également des dispositifs implantables comprenant un revêtement de gel d'alginate homogène. L'invention concerne en outre des procédés permettant d'améliorer la viabilité d'îlots pancréatiques, ou d'autres tissus ou agrégats cellulaires, après isolation et pendant le stockage et le transport.

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