C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2192957
Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
L'invention concerne des oligopeptides comprenant des séquences d'acides aminés reconnues et clivées protéolytiquement par un antigène spécifique de la prostate (PSA). L'invention concerne également des dosages comprenant ces oligopeptides utiles pour déterminer l'activité de la protéase de PSA libre in vitro et in vivo. En outre, l'invention concerne des agents thérapeutiques comprenant des conjugués de ces oligopeptides ainsi que des agents cytotoxiques connus.
Defeo-Jones Deborah
Feng Dong-Mei
Garsky Victor M.
Jones Raymond E.
Oliff Allen I.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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