Semi-synthesis and isolation of taxane intermediates from a...

Details Semi-synthesis and isolation of taxane intermediates from a... Semi-synthesis and isolation of taxane intermediates from a...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01)

Patent

CA 2563838

A process is provided for the semi-synthesis and isolation of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis and isolation of 10-deacetylbaccatin III, the semi-synthesis of a mixture of 10-deacetylbaccatin III and baccatin III, and protected derivatives thereof, from a mixture of taxanes.

L'invention concerne un procédé de semi-synthèse et d'isolement d'intermédiaires du taxane utilisés dans la préparation du paclitaxel et du docetaxel, en particulier dans la semi-synthèse et l'isolement de la 10-deacétylbaccatine III, la semi-synthèse d'un mélange de 10-deacétylbaccatine III et de baccatine III, et de dérivés protégés de ces derniers, à partir d'un mélange de taxanes.

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