Semi-synthesis of insulin

C - Chemistry – Metallurgy – 12 – P

Patent

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195/128.2

C12P 21/06 (2006.01) C07K 14/62 (2006.01)

Patent

CA 1145697

ABSTRACT A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

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