Semi-synthesis of paclitaxel using dialkyldichlorosilanes

Details Semi-synthesis of paclitaxel using dialkyldichlorosilanes Semi-synthesis of paclitaxel using dialkyldichlorosilanes

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01)

Patent

CA 2375253

A process for the synthesis of paclitaxel from 10-deacetylbaccatin-III which is protected at the 7-position with a dialkylalkoxysilyl protecting group having the formula -Si(R)2(OR').

Cette invention se rapporte à un procédé réalisant la synthèse de paclitaxel à partir de 10-déacétylbaccatine-III, qui est protégé à la position 7 avec un groupe protecteur dialkylalcoxysilyle représenté par la formule -Si(R)¿2?(OR').

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