Semi-synthesis of taxane derivatives using metal alkoxides...

C - Chemistry – Metallurgy – 07 – D

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C07D 305/14 (2006.01) C07D 265/06 (2006.01)

Patent

CA 2092962

A process for preparing taxane derivatives taxol by providing a metal alkoxide having the bi, tri-, or tetracyclic taxane nucleus, reacting the metal alkoxide with an oxazinone to form an intermediate, and converting the intermediate to the taxane derivative.

Méthode pour préparer des dérivés du taxane, comme le taxol, à partir d'un alcoxyde métallique avec noyau taxane bi, tri ou tétracyclique, en faisant réagir cet alcoxyde métallique avec une oxazinone pour former un produit intermédiaire, puis en convertissant ce dernier produit en dérivé du taxane.

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