Semi-synthetic ecteinascidins

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 515/22 (2006.01) A61K 31/495 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2327468

The present invention is directed to several newly prepared semi-synthetic ecteinascidin (Et) species, designated herein as Et 757, Boc-Et 729, Iso-Et 743, Et 875, and Et 1560. The physical properties of these compounds, their preparation and bioactivities are also reported.

La présente invention se rapporte à plusieurs espèces nouvellement conçues d'actéine-ascidines semi-synthétiques (Et), désignées ici Et 757, Boc-Et 729, Iso-Et 743, Et 875 et Et 1560. L'invention concerne également les propriétés physiques de ces composés, leur préparation et leurs activités biologiques.

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