Semi-synthetic preparation of human insulin

Details Semi-synthetic preparation of human insulin Semi-synthetic preparation of human insulin

C - Chemistry, Metallurgy

12

P

195/128.2, 530/7

C12P 21/04 (2006.01) C07K 14/62 (2006.01)

Patent

CA 1202587

ABSTRACT Human insulin is semi-synthetically prepared using a novel method comprising the preparation of a modified human insulin of the general formula Image wherein R = H or an enzymatically separable sugar residue or an ester thereof, and R1 = an enzymatically separable sugar residue or an ester thereof, or an amino acid or peptide, or an amide or ester of the latter two, or R1 = OH if R?H, followed by enzymatic removal of the modifying groups R and/or R1 to yield human insulin.

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