C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/12 (2006.01) A61K 31/415 (2006.01) A61K 31/4523 (2006.01) A61K 31/5377 (2006.01) C07D 231/54 (2006.01) C07D 401/12 (2006.01) C07D 413/02 (2006.01)
Patent
CA 2453104
The present invention relates to the synthesis of a new class of 5-substituted- 3-(4-OR1-phenyl)-2H-indeno[1,2-c]pyrazol-4-ones of formula (I) : formula (I) that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
La présente invention concerne la synthèse d'une nouvelle classe de 3-(4-OR?1¿-phényl)-2H-indéno[1,2-c]pyrazol-4-ones substituées en 5 de formule (I). Ces composés constituent des inhibiteurs potentiels de la classe des enzymes connues sous le nom de kinases dépendantes des cyclines, lesquelles regroupent les sous-unités catalytiques cdk1-7 et leurs sous-unités régulatrices appelées cyclines A-G. L'invention concerne également une nouvelle méthode permettant de traiter le cancer ou d'autres maladies prolifératives, par administration d'une dose thérapeutiquement efficace d'un de ces composés ou de sels pharmaceutiquement acceptables de ces derniers. L'invention se rapporte en outre à une méthode destinée à traiter le cancer ou d'autres maladies prolifératives par administration d'une combinaison thérapeutiquement efficace comprenant un des composés selon la présente invention et un ou plusieurs agents anti-cancéreux ou anti-prolifératifs.
Bereskin & Parr
Bristol-Myers Squibb Pharma Company
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