C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/496 (2006.01) A61P 35/00 (2006.01) C07D 231/54 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2430376
The present invention relates to the synthesis of a new class of indeno[1,2- c]pyrazol-4-ones of formula (I) that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti- proliferative agents.
La présente invention concerne la synthèse d'une nouvelle classe d'indéno[1,2-c]pyrazol-4-ones de formule (I) qui sont de puissants inhibiteurs des enzymes connues sous le nom de kinases dépendantes des cyclines, qui sont apparentées aux sous unités catalytiques cdk1-7 et à leur sous unités régulatrices connues sous le nom de cyclines A-G. Cette invention concerne aussi une méthode de traitement du cancer ou d'autres maladies prolifératives par administration d'une quantité thérapeutiquement efficace de l'un de ces composés ou d'un sel pharmaceutiquement acceptable desdits composés. Dans une variante, on peut traiter le cancer ou d'autres maladies prolifératives en administrant une combinaison thérapeutiquement efficace de l'un de ces composés et d'un ou plusieurs autres agents anticancéreux ou antiprolifératifs connus.
Bristol-Myers Squibb Pharma Company
Piasetzki & Nenniger Llp
LandOfFree
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